In the world of biochemical research, few molecules have piqued as much curiosity as t Nov 11, 2024—Azurinand itsderived peptides, particularlyp28,haveshown strong anticancer effects, primarily duetotheir capacitytostabilize the Read more he azurin-derived cell-penetrating peptide p28. As someone who follows advancements in peptide science, I have often explored the potential of these unique structures. The journey to understand this specific molecule—often labeled as NSC 745104—involves navigating complex scientific literature and understanding the nuances of sourcing research-grade materials.
Understanding the Entity: What is p28?
To appreciate why researchers are interested in this molecule, one must first look at its origin. Azurin is a cupredoxin secreted by the opportunistic pathogen *Pseudomonas aeruginosa*. The p28 peptide is effectively a 28-amino-acid segment (Leu50- by T Yamada·2013·Cited by 118—A 28 amino-acid (aa)cell-penetrating peptide(p28)derivedfromazurin, a redox protein secreted from the opportunistic pathogen Pseudomonas Asp77) of this redox protein.
From a structural standpoint, p28 is an amphipathic, α-helical, cell penetrating peptide. Unlike many standard cationic peptides, p28 is notable for being an anionic cell-penetrating peptide. This unique characteristic is what allows it to interact with its targets, such as the p53 tumor suppressor protein. In my research, I have found that p28 is derived from azurin to function as a tool fo Azurin p28 peptide | Research Reagent — Buy Online r studying protein-protein interactions, specifically the stabilization of p53 by inhibiting its proteasomal degradation.
Navigating Availability and Research Sourcing
When users search for "azurin-derived cell-penetrating p Thep28is a small-sizedcell-penetrating peptide derivedfrom bacterial proteinazurinandcanfunction as a cancer-specific anti-proliferative agent. eptide p28 where can i get," they often encounter a fragmented landscape. It is important to note that the availability of this specific reagent can be inconsistent. In some instances, specialized suppliers have listed the Azurin p28 peptide as having been withdrawn from sale for commercial reasons.
However, for those in academic or laboratory settings, you may still see listings for:
* Azurin p28 peptide TFA: This trifluoroacetate salt form is a common variant used in experimental protocols.
* Research-grade synthesis: Several chemical suppliers offer the pept Azurin p28 peptide | p53 ide with purity levels of ≥99%, verified by HPLC and mass spectrometry.
If you are looking to buy Azurin NCT00914914 | Safety Study of a Cell Penetrating Peptide p28 peptide, you must ensure that the supplier provides a Certificate of Analysis (COA) and a Safety Data Sheet (SDS). Because p28 is a research reagent, it is not intended for any other purpose. Always verify that your source is reputable, as the supply chain for niche peptides can fluctuate significantly.
Scientific Context and Mechanisms
The mechanism of p28 is fascinating. As a cell penetrating peptide, it possesses the ability to cross cellular membranes. Researchers have observed that p28 can preferentially enter specific cell types, which has made it a subject of extensive study in the context of cell cycle arrest and apoptotic pathways.
The interaction between the p28:p53 complex is a primary focus of many studies. By binding to the DNA-binding domain of p53, the peptide influences the post-translational stability of the protein. We have seen that this modulation is critical for the peptide's reported biological activity. Furthermore, its ability to act as a tumor-homing peptide continues to be a subject of intense investigation in preclinical models.
Final Thoughts on Sourcing
When you search for where to get this peptide, remember that you are dealing with a specialized research tool. The "Azurin p28 peptide" is not a standard commodity. Suppliers like Aladdin Scientific or other chemical distributors may list it, but availability depends heavily on their current production cycles.
If you are a researcher, the best approach is to contact reputable chemical synthesis houses directly. They can often perform custom synthesis if the catalog item is currently unavailable. Always prioritize purity and verifiable documentation to ensure your experimental results remain consistent.
*Disclaimer: This article is for informational purposes only and describes research-grade biochemical r p28, A first in class peptide inhibitor of cop1 binding to p53 eagents. It does not provide medical or clinical advice.*