In the evolving field of biochemical research, specific molecular tools have become indispensable for studying cellular signaling pathways. One such molecule that frequently appears in academic literature is D-JNKI-1 peptid D-jnki-1 | C164H285N65O41 | CID 72941992 - PubChem e. Often categorized as a highly specialized research reagent, this compound has garnered significant attention for its unique ability to modulate complex intracellular pro c-Jun N-terminal kinase cesses.
What is D-JNKI-1 Peptide?
D-JNKI-1, also known in various research circles as AM-111, XG-102, or Brimapitide, is a synthetic, cell-permeable peptide inhibitor. It is a protein-based compound currently being studied in clinical trials for its role as a highly potent and cell-permeable peptide inhibitor It classifies substances as chemical, protein, nucleic acid, polymer, structurally diverse, or mixture as detailed in the ISO 11238 (International Organization Read more of JNK (c-Jun N-terminal kinase).
From a structural perspective, D-JNKI-1 is a 31-amino acid sequence designed to mimic the JNK-binding domain of the JNK-interacting protein-1 (JIP-1). By acting as a competitive inhibitor, it prevents the JNK stress kinase from phosphorylating its target substrates. Because it is a synthetic, cell permeable peptide that blocks the MAPK-JNK signal pathway, it has become a standard tool in laboratories aiming to investigate the downstream effects of JNK activation.
Key Characteristics and Mechanism
The primary utility of this peptide lies in its specificity. D-JNKI-1 is an efficient inhibitor of the action of all three JNK isoforms. When researchers analyze the molecule, they often point to its stabilit by Y Zhao·2012·Cited by 51—The JNK peptide inhibitor,D-JNKI-1(XG-102) reversed these pathological events in the mitochondria and almost completely abolished cytochrome c release and Read more y; as a D-amino acid-based peptide, it exhibits increased resistance to proteolytic degradation compared to its L-isomer counterparts.
Key technical specifications of the material include:
* Molecular Formula: C164H285N65O41
* CAS Number: 1445179-97-4
* Molecular Weight: Approximately 3822.44 g/mol
* Nature: High-purity peptide inhibitor
The mechanism is elegant in its simplicity: by occupying the docking site on the JNK protein, it prevents the kinase from interacting with its physiological partners, effectively silencing the signaling cascade.
Research Applications and Observations
In the laboratory setting, the application of D-JNKI-1 has provided fascinating insights. D-JNKI-1 | CAS 1445179-97-4 For instance, studies have shown that D-JNKI-1 (AM-111) can influence cellular responses in various experimental models.
Cellular Protection Studies
One of the most cited observations in literature is that D-JNKI-1 treatment increased the number of +/Lc PC (Purkinje cells) at 14 DIV of 3.6-fold in specific culture environments. Furthermore, researchers have noted that the peptide prevents nearly all hair cell death and permanent hearing loss in controlled experimental models of ototoxicity. This has led to widespread interest in the potential for this peptide to provide protection against permanent sensorineural hearing l The JNK Signaling Pathway in Inflammatory Skin Disorders and oss in preclinical scenarios.
Neurobiological Research
The role of JNKs in neurodegenerative disease is a significant area of inquiry. Because JNKs mediate neuronal damage in neurodegenerative disease, the use of D-JNKI-1 has been instrumental in exploring whether blocking this pathway can mitigate cellular stress. In models of transient focal cerebral ischemia, the administration of this peptide has been observed to promote functional recovery, highlighting its importance in experimental neurology.
Mitochondrial Health
The intersection of peptide research and mitochondrial function is profound. DJ-1 is a vital enzyme involved in the maintenance of mitochondrial health, and the regulation of pathways surrounding it is a hot topic. By suppressing reactive oxygen species (ROS) generation, D-JNKI-1 helps maintain the delicate balance required for mitochondrial integrity.
Exploring Variations and Related Compounds
While D-JNKI-1 is the primary focus for many, researchers often compare it to other related agents. For example, L-JNKI-1 is a cell-permeable peptide inhibitor that, while similar in function, may differ in pharmaco JNKs mediate neuronal damage in neurodegenerative diseaseand inhibitors of JNK1 have shown anxiolytic and anti-depressive effects in mice. Here, we analyze the Read more kinetic profiles. Additionally, researchers looking for alternatives or experimental controls often i MedChemExpress D-JNKI-1 10 mg | Buy Online nvestigate compounds like P13 peptide or Brimapitide, which is the international non-proprietary name often associated with the clinical development of this class of inhibitors.
Summary of Findings
Whether you are looking at D-JNKI-1 as a tool for signal modulation or studying its effects on specific kinase isoforms, it remains a cornerstone of modern peptide research. Its ability to act as a highl Function, D-JNKI-1 (AM-111)is a highly potent and cell-permeable peptide inhibitor of JNK. ; Product Type, Peptide ; Cas, 1445179-97-4 ; Molecular Weight, 3822.44 Read more y selective, non-competitive, long-acting inhibitor makes it a preferred choice for those studying the JNK pathway. As research continues, the data gathered from these experiments—especially regarding its role in cellular survival and signaling—will undoubtedly continue to refine our understanding of molecular biology.
*Note: This content is intended for informational and educational purposes based on existing scientific literature and does not constitute medical advice, diagnosis, or treatment recommendations.*