In the evolving field of peptide chemistry, researchers and enthusiasts frequently encounter specialized compound By suppressing α-MSH–driven melanogenic pathways, it reduces basal melanin synthesis and reverses UVA-induced pigmentation in human melanocytes and HaCaT cells. s designed for precise molecular interactions. One such compound that has Nonapeptide-1 (Melanostatine-5) acetate salt, a peptide hormone, functions as a selective and competitive antagonist of the melanocortin 1 receptor (MC1R) g Nonapeptide-1 acetate salt (158563-45-2 free base) ained significant attention in laboratory research settings is Nonapeptide-1 acetate salt. As someone who follows advancements in biochemical research, I have found the structural complexity and functional specificity of this particular molecule to be a fascinating subject for study.
Understanding the Molecular Profile
Nonapeptide-1 acetate salt (often referred to in research as Melanostatine-5) is a synthetic peptide consisting of a specific sequence: Met-Pro-D-Phe-Arg-D-Trp-Phe-Lys-Pro-Val-NH2. With a molecular weight of approximately 1206.5 Da and the chemical formula C61H87N15O9S, it is categorized as a biomimetic peptide.
From a biochemical standpoint, Nonapeptide-1 is a bionic peptid Nonapeptide-1acetatesalt是一种多肽激素，是强效的α-黑色素细胞刺激激素(α-MSH)的拮抗剂，其IC50值为11nM。减少黑色素的合成，在很大程度上帮助减少皮肤色素沉着。 e that exhibits a high affinity for the melanocortin 1 receptor (MC1R) located on the surface of melanocytes. By binding to this receptor, it functions as a potent antagonist of the α-melanocyte-stimulating hormone (α-MSH) receptor. This mechanism is crucial for researchers investigating the regulation of pigmentation pathways.
Mechanisms in Research
The primary interest in this compound stems from its Nonapeptide-1 is a bionic peptide that has a good match with the melanocortin 1 receptor (MC1R) on melanocytes, so it can act as a antagonist of melanocyte- role as an antagonist. Specifically, Nonapeptide-1 acetate salt is a potent α-Melanocyte-stimulating hormone (α-MSH) antagonist with an IC50 value of approximately 11 nM. By effectively blocking the binding of α-MSH Nonapeptide-1 | C61H87N15O9S | CID 10418849 - structure, chemical names, physical and chemical properties, classification, patents, literature, to the MC1R, it prevents the subsequent activation of intracellular signaling pathways that lead to melanin production.
In various experimental models, including studies on human melanocytes and HaCaT cells, this interaction has been shown to reduce basal melanin synthesis. Because Nonapeptide-1 (Melanostatine-5) acetate salt interferes with the action of tyrosinase—the key enzyme in the melanogenesis process—it is frequently utilized in studies aiming to understand how to modulate pigmentation at a cellular level. Furthermore, Nonapeptide-1 may demonstrate potential in animal studies to diminish skin pigmentation, providing valuable data on how these pathways respond to competitive inhibition in living systems.
Practical Considerations for Research Use
When sourcing this compound for laboratory use, purity and handling are paramount. Most high-quality suppliers provide Nonapeptide-1 (acetate) as a crystalline solid with a purity level exceeding 95% or even 99%.
Researchers often look for the following specif Nonapeptide1 acetate salt (158563452 free base) ications:
* Chemical Identity: Nonapeptide-1 acetate salt (CAS 158563-45-2).
* Biological Activity: Selective MC1R antagonism.
* Research Application: Often explored in the development of topical formulations, such as a BRIGHTENING & SKIN-SMOOTHING SERUM, where the goal is to evaluate the peptide's efficacy in stabilizing skin tone.
It is important to note that Nonapeptide-1 is a synthetic peptide designed specifically for research and cosmetic ingredient evaluation. Because it is a peptide hormone analog, it requires careful storage—typically at -20°C in a dry environment—to maintain its structural integrity and ensure the reliability of experimental outcomes.
Conclusion
The study of Nonapeptide-1 continues to provide insights into the complex signaling cascades governing pigmentation. Whether one is referring to it as Nonapeptide-1 acetate salt or by its synonym, Melanostatine-5, the compound's ability to act as a potent α-Melanocyte-stimulating hormone (α-MSH) antagonist makes it an indispensable tool for those studying dermatological molecular pathways. Nonapeptide1 acetate salt (158563452 free base)
As with any specialized biochemical agent, the key to successful application lies in understanding its specific inhibitory concentration (IC50) and its interaction with the MC1R. As research progresses, we will likely see further documentation on how this molecule can be effectively utilized to influence cellular pigmentation processes in controlled, non-clinical research environments.