In the evolving fiel Fmoc-2-(4-Pentenyl)-Ala-OH | 288617-73-2 d of synthetic chemistry, researchers are constantly seeking innovative building blocks to enhance the structural integrity o 288617-73-2 | (S)-N-Fmoc-α-(4-Pentenyl)alanine, 98% f molecular chains. One such component that has garnered significant attention is stapled peptide s 5 288617-73-2, formally known as Fmoc-(S)-2-(4-pentenyl)alanine. As someone who follows advancements in laboratory techniques, I have found that this specific unnatural amino acid serves as a cornerstone for creating robust molecular architectures.
What is Fmoc-(S)-2-(4-pentenyl)alanine?
At its core, CAS Number: 288617-73-2 is an Fmoc-protected, alkenyl-functionalized amino acid. Often referred to as Fmoc-(S5)-OH, this molecule is a critical product used for preparing stapled peptides. By incorporating this building block into a sequence, chemists can utilize Fmoc-(S)-2-(4-pentenyl)alanine [288617-73-2] ring-closing olefin metathesis to create a hydrocarbon bridge, or "staple," which serves to lock the peptide into a specific conformation.
When Chemical Name, (S)-N-Fmoc-2-(4'-pentenyl)alanine. CAS Number, 288617-73-2. Molecular Formula, C23H25NO4. Molecular Weight, 379.45. Synonyms, Fmoc-S5-OH Read more we discuss stapled peptides, we are looking at molecules that have been engineered for increased stability. The process involves the introduction of a chemical brace at specific positions—typically the i and i+4 or i and i+7 positions—to stabilize the alpha-helical structure.
Key Properties and Technical Specifications
For those working in the lab, understanding the technical specifications of this building block is essential. Below are the standard parameters for Fmoc-(S)-2-(4-pentenyl)Ala-OH:
* Molecular Formula: C23H25NO4
* Molecular Weight: 379.45 g/mol
* Synonyms: (S)-N-Fmoc-2-(4'-pentenyl)alanine, Fmoc-alpha-Me-Gly(Pentenyl)-OH, or S)-N-Fmoc-2-(4-pentenyl)alanine.
* MDL Number: MFCD09879888
This stapled peptide building block is generally stored under controlled conditions (typically below 5°C) to maintain its reactivity. It is a vital tool for those focusing on application: peptide synthesis, providing the necessary functionality to bridge amino acid chains effectively.
The Utility of Hydrocarbon Stapling
The primary reason researchers utilize hydrocarbon stapled peptides is to overcome the inherent flexibility of natural sequences. By using Fmoc-(S)-2-(4-pentenyl)alanine (Fmoc-(S5)-OH, CAS: 288617-73-2), scientists can achieve a rigid, pre-organized structure. This is not just theoretical; it is a practical approach used in the synthesis of complex molecules. For instance, ALRN-6924 is synthesized using Fmoc-(S)-2-(4-pentenyl)alanine (Fmoc-(S5)-OH, CAS: 288617-73-2), demonstrating the real-world utility of this reagent.
Furthermore, hydrocarbon-stapling of natural peptides is widely recognized for enhancing protease resistance and improving conformational stability. Whether you are working with Fmoc-(R)-2-(5-hexenyl)alanine or the S variant, the ability to fine-tune the "staple" length allows for precise control over the molecular design.
Integrating Stapled Peptide S into Research
When working with 288617-73-2, it is helpful to keep the section 5 safety guidelines in mind, as this is a laboratory chemical that requires careful handling. From my experience, the quality of the building block—o 288617-73-2 | Fmoc-α-Me-Gly(Pentenyl)-OH ften cited as ≥97% or 98% assay—is paramount for succ SKU: SKU-3594 Category: Alkenyl Building Blocks forStapled Peptides. PurchaseStapled peptide;S(5);288617-73-2. Package Size. Choose an option, 1g, 5g. Clear Read more essful synthesis.
The incorporation of Fmoc-2-(4-Pentenyl)-Ala-OH into a stapled sequence is a testament to how far peptide chemistry has come. By moving beyond traditional natural amino acids, we are now able to construct molecules that exhibit enhanced properties that were previously difficult to achieve. Whether you are exploring Fmoc-α-Me-Gly(Pentenyl)-OH or other alkenyl building blocks for stapled peptides, the prec eMolecules Ambeed / (S)-N-Fmoc--(4-pentenyl)alanine / 250mg / 552570390 / A136002 / /288617-73-2/ MFCD09879888 / 379.456 / C23H25NO4 5.44 / Pack of5.Read more ision offered by these tools continues to drive the field forward.
In summary, the use of stapled peptide technology represents a sophisticated leap in synthetic methodologies. By utilizing high-quality precursors like 288617, researchers can continue to explore the vast potential of stabilized helical structures in various experimental applications.